The inhibition of myeloperoxidase by ceruloplasmin can be reversed by anti-myeloperoxidase antibodies
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چکیده
منابع مشابه
Inhibition of myeloperoxidase by salicylhydroxamic acid.
Salicylhydroxamic acid inhibited the luminol-dependent chemiluminescence of human neutrophils stimulated by phorbol 12-myristate 13-acetate or the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMet-Leu-Phe). This compound had no inhibitory effect on the kinetics of O2.- generation or O2 uptake during the respiratory burst, but inhibited both the peroxidative activity of purified m...
متن کاملCeruloplasmin is an endogenous inhibitor of myeloperoxidase.
Myeloperoxidase is a neutrophil enzyme that promotes oxidative stress in numerous inflammatory pathologies. It uses hydrogen peroxide to catalyze the production of strong oxidants including chlorine bleach and free radicals. A physiological defense against the inappropriate action of this enzyme has yet to be identified. We found that myeloperoxidase oxidized 75% of the ascorbate in plasma from...
متن کاملMaintenance of tolerance by regulation of anti-myeloperoxidase B cells.
Anti-neutrophil cytoplasmic autoantibodies directed toward myeloperoxidase or proteinase 3 are detected in sera of patients with small vessel vasculitis and participate in the pathogenesis of this disease. Autoantibodies develop when self-reactive B cells escape the regulation that ensures self-tolerance. In this study, regulation of anti-myeloperoxidase B cells was examined in mice that expres...
متن کاملInhibition of myeloperoxidase-catalyzed tyrosylation by phenolic antioxidants in vitro.
We have developed an in vitro assay system for the evaluation of the inhibitory effects of phenolic antioxidants on myeloperoxidase (MPO) activity. The formation of dityrosine from the MPO/H2O2/L-tyrosine system was used as an indicator of the MPO activity. Because the buffer system used does not include chloride ion, this assay has the advantage of exclusion of direct reaction between an antio...
متن کاملAnti-Myeloperoxidase Antibodies Associate with Future Proliferative Lupus Nephritis
Background The subclinical pathophysiology of proliferative lupus nephritis (PLN) has not been fully elucidated. Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) is associated with PLN, but prediagnostic levels have not been reported. Methods We performed a retrospective case-control Department of Defense Serum Repository (DoDSR) study comparing MPO-ANCA levels in longitudinal ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1999
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1999.055003917.x